Isolation means, according to the Cambridge Dictionary: the condition of being alone, especially when this makes you feel unhappy; the fact that something is separate and not connected to other things.
Isolation either by oneself or man can be detrimental to your psychey. I don’t like using the word isolation when concerning God I rather say retreat. The definition of retreat: an act or process of withdrawing especially from what is difficult, dangerous, or disagreeable: a period of group withdrawal for prayer, medition, study, or instruction under a director, Merriam-webster dictionary.
If in Genesis 2:18 God says, it’s not good for man to be alone. I will make a helper suitable for him. If God isolates you it is because He’s your suitable helper for that period of time. Never to leave you alone, to be tempted and tortured by your own thoughts and feelings and worst, giving way to the devil. The Lord always has a plan for us and His plan is for good and not to hurt you, Jeremiah 29:11. This is how we can discern that if God allows isolation in our lives, it would not leave us broken. It edify, up lefts and draw us nearer to God, especially in obedience for the good of others as well as ourselves. Take a look at Jonah, after being in the belly of the whale for three days, Jonah 1:17.
So to retreat (isolate) is hard to endure without faith to bring you through to the other side of wisdom, knowledge and understanding instead of brokenness.